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Home Sports Nutrition

DHEA Dietary supplements: Every thing You Have to Know

Admin by Admin
February 21, 2025
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DHEA Dietary supplements: Every thing You Have to Know
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Getting old comes with a value: declining hormones, muscle loss, and decrease vitality ranges.

DHEA is usually marketed as a repair for all of this. Some even declare it may possibly reverse growing older completely. 

However does the science again it up?

The reality is, DHEA isn’t a miracle complement, however it does have actual, research-backed advantages. If you happen to’re seeking to assist wholesome hormone ranges, preserve muscle, and counteract among the results of growing older, DHEA is perhaps value contemplating.

On this article, you’ll study what DHEA is, what it does, and how one can spot the perfect DHEA complement for you.

Key Takeaways

  • DHEA is a steroid hormone your physique makes use of to supply testosterone and estrogen. Its ranges decline with age, which is why some older folks select to complement with it.
  • DHEA will increase testosterone in males and estrogen in girls, so it might show you how to preserve muscle, cut back fats, and decrease among the downsides of growing older.
  • Whereas DHEA could assist hormone steadiness and physique composition, its results are modest and work greatest if you mix it with power coaching and a nutritious diet.
  • Most research use doses of 25-to-200 mg per day, with 50-to-100 mg being the simplest vary. Increased doses could improve estrogen ranges—one thing you might wish to keep away from.
  • DHEA is usually secure, however excessive doses may cause delicate negative effects like oily pores and skin and elevated physique hair. If you happen to’re an expert athlete, take into accout it’s banned by main sports activities organizations.

What Is DHEA?

DHEA, or dehydroepiandrosterone (dee-hydro-epi-and-rost-erone), is a steroid hormone primarily produced by your physique’s adrenal glands.

As with different steroid hormones like testosterone and estrogen, DHEA’s pure manufacturing peaks in younger maturity and declines by round 10% every decade till across the age of 70.

Scientists additionally produce artificial variations of DHEA from chemical substances in wild yam and soy known as diosgenin and genistein, which complement producers usually use to create dietary dietary supplements. When taken often, these dietary supplements elevate your physique’s degree of DHEA.

Regardless of being found in 1934, scientists nonetheless don’t absolutely perceive DHEA’s function inside the physique. That is largely as a result of:

  1. DHEA is an endogenous metabolite that can’t be patented, which suggests pharmaceutical firms aren’t thinking about supporting analysis into its makes use of.
  2. DHEA is basically distinctive to people, which makes it tough to review its results in different animals (an necessary step when researching new substances). 

One factor scientists are positive about is that DHEA is a precursor to testosterone and estrogen. In different phrases, the physique makes use of DHEA as uncooked materials for making testosterone and estrogen.

And it’s because of this that DHEA dietary supplements are standard amongst folks seeking to optimize their well being and efficiency. 

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DHEA Advantages

Complement firms market DHEA as a repair for all the things from coronary heart illness to autoimmune problems, however most of those claims lack sturdy proof.

As an alternative of getting misplaced in hypothesis, let’s concentrate on what analysis truly exhibits DHEA can do.

Hormonal Stability

Analysis exhibits that supplementing with DHEA reliably will increase testosterone in males and estrogen in girls, notably in these whose ranges have declined with age.

In males, larger testosterone ranges could assist gradual age-related muscle loss, increase vitality, and assist metabolic well being.

In girls, DHEA raises estrogen, which could alleviate some signs of menopause like scorching flashes, nervousness, and despair. Some analysis additionally hyperlinks DHEA to enhancements in sexual perform and psychological well-being.

Whereas DHEA’s results on hormone ranges are well-established, the downstream advantages can range.

Some folks discover enhancements in temper, libido, and total vitality, whereas for others, the advantages are much less pronounced. Both method, for these coping with age-related hormonal decline, DHEA supplementation affords a method to restore steadiness.

Improved Physique Composition

Research present that taking DHEA might help older adults construct muscle and lose physique fats.

If you happen to’re a person, this possible occurs as a result of larger testosterone ranges make it simpler to enhance your physique composition. To be clear, nevertheless, DHEA gained’t show you how to construct muscle like steroids or TRT.

If you happen to’re a girl, larger estrogen ranges could assist you protect muscle and bone whereas limiting fats acquire, notably after menopause. Some analysis additionally suggests DHEA can enhance your insulin sensitivity, which helps metabolic well being and makes it simpler to handle your weight.

In different phrases, whereas DHEA alone gained’t drastically remodel your physique, supplementing with it—particularly alongside power coaching and a correct weight loss program—could assist offset among the physique composition modifications that include growing older.

Wholesome Getting old

As we’ve seen, supplementing with DHEA could assist offset lots of the downsides of growing older, together with hormonal imbalance, muscle loss, fats acquire, and declining metabolic well being. And this helps you protect extra of the vitality and vigor of your youth.

Analysis additionally suggests it might assist cognitive efficiency, enhance sexual perform, improve power, and improve psychological well-being. These potential advantages are necessary as a result of they contribute to total high quality of life—serving to you keep bodily succesful, mentally sharp, and extra resilient as you age.

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DHEA Facet Results

Most analysis exhibits that average doses of DHEA are secure and trigger few—if any—negative effects.

Nevertheless, larger doses can generally lead to oily pores and skin, pimples, and elevated physique hair development in areas just like the face, armpits, or pubic area. These negative effects are uncommon and normally short-term.

If you happen to’re over 70 or have any current medical situations, seek the advice of a healthcare skilled earlier than utilizing DHEA to make sure it’s appropriate for you.

What Is the Clinically Efficient Dose of DHEA?

Most research use doses of 25-to-200 mg per day, with 50-to-100 mg being probably the most well-researched and efficient vary.

Analysis exhibits that doses above 50 mg per day increase testosterone ranges extra successfully than decrease doses however may additionally improve estrogen ranges, which many individuals would favor to keep away from.

What Is the Finest DHEA Complement?

To be thought-about the perfect DHEA complement, a product should:

  • Comprise a clinically efficient dose of DHEA
  • Comprise no synthetic fillers, meals dyes, or different chemical junk
  • Be analyzed for purity and efficiency in an accredited lab
  • Have a clear and clear label displaying precisely what’s in each serving and what’s not (no proprietary blends or hidden substances)
  • Be made in NSF-certified and FDA-inspected and cGMP-compliant services

For a product that meets all these standards, attempt Legion’s DHEA complement.

FAQ #1: Is DHEA secure for ladies?

Sure. The truth is, there are some potential advantages of DHEA which can be female-specific, together with:

  • Improved bone mineral density
  • Elevated success with in vitro fertilization (IVF) therapy
  • Improved sexual perform and elevated libido
  • Improved psychological well-being
  • Decreased ache throughout sexual exercise 

FAQ #2: Is DHEA a steroid? 

Not precisely. DHEA is a steroid hormone produced naturally by the physique, which could be very completely different from medicine usually known as steroids.

After we discuss with steroids in a bodybuilding or sports activities context, these are sometimes unnatural substances generally known as anabolic-androgenic steroids (AAS) that may behave in related methods to pure hormones like testosterone and estrogen. Nevertheless, they’re taken at doses with results that far exceed what pure hormones would do.

The dose of DHEA in Vitality can be effectively inside the quantity naturally produced by the physique, and thus bears little resemblance to AAS.

FAQ #3: Is DHEA a banned substance?

For skilled athletes, sure. For everybody else, no. DHEA is assessed as an “anabolic agent,” and thus its use by skilled athletes on the earth’s largest sporting organizations is prohibited by the World Anti-Doping Company (WADA) and the United States Anti-Doping Company (USADA).

FAQ #4: How lengthy does it take for DHEA to work?

Whereas some folks report extra vitality inside weeks of taking DHEA, most research see the biggest enhancements in well being and well-being after 3-to-6 months of continued use. 

FAQ #5: Does DHEA trigger weight acquire?

Supplementing with DHEA normally doesn’t trigger weight acquire. It might show you how to construct a small quantity of muscle and cut back fats, however these modifications usually steadiness out, so the dimensions stays the identical.

Scientific References +

  1. Webb, Stephanie J., et al. “THE BIOLOGICAL ACTIONS of DEHYDROEPIANDROSTERONE INVOLVES MULTIPLE RECEPTORS.” Drug Metabolism Opinions, vol. 38, no. 1-2, 2006, pp. 89–116, www.ncbi.nlm.nih.gov/pmc/articles/PMC2423429/, https://doi.org/10.1080/03602530600569877. Accessed 10 Nov. 2021.
  2. Orentreich, N, et al. “Age Modifications and Intercourse Variations in Serum Dehydroepiandrosterone Sulfate Concentrations all through Maturity.” The Journal of Medical Endocrinology and Metabolism, vol. 59, no. 3, 1984, pp. 551–5, www.ncbi.nlm.nih.gov/pubmed/6235241, https://doi.org/10.1210/jcem-59-3-551. Accessed 23 Jan. 2020.
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  5. Corrigan, Brian. “DHEA and Sport.” Medical Journal of Sport Medication, vol. 12, no. 4, July 2002, pp. 236–241, https://doi.org/10.1097/00042752-200207000-00006. Accessed 23 Could 2021.
  6. Yen, et al. Substitute of DHEA in Getting old Males and Ladies. Vol. 774, no. 1 Dehydroepiand, 1 Dec. 1995, pp. 128–142, https://doi.org/10.1111/j.1749-6632.1995.tb17377.x. Accessed 2 Aug. 2023.
  7. Liu, Te-Chih, et al. “Impact of Acute DHEA Administration on Free Testosterone in Center-Aged and Younger Males Following Excessive-Depth Interval Coaching.” European Journal of Utilized Physiology, vol. 113, no. 7, 17 Feb. 2013, pp. 1783–1792, https://doi.org/10.1007/s00421-013-2607-x. Accessed 21 Jan. 2022.
  8. Genazzani, Alessandro D, et al. Lengthy-Time period Low-Dose Dehydroepiandrosterone Oral Supplementation in Early and Late Postmenopausal Ladies Modulates Endocrine Parameters and Synthesis of Neuroactive Steroids. Vol. 80, no. 6, 1 Dec. 2003, pp. 1495–1501, https://doi.org/10.1016/j.fertnstert.2003.06.005. Accessed 30 July 2023.
  9. Corona, Giovanni, et al. “Dehydroepiandrosterone Supplementation in Aged Males: A Meta-Evaluation Examine of Placebo-Managed Trials.” The Journal of Medical Endocrinology & Metabolism, vol. 98, no. 9, 1 Sept. 2013, pp. 3615–3626, tutorial.oup.com/jcem/article/98/9/3615/2833096, https://doi.org/10.1210/jc.2013-1358. Accessed 23 June 2022.
  10. Wang, Furong, et al. “The Results of Dehydroepiandrosterone (DHEA) Supplementation on Physique Composition and Blood Stress: A Meta-Evaluation of Randomized Medical Trials.” Steroids, vol. 163, Nov. 2020, p. 108710, https://doi.org/10.1016/j.steroids.2020.108710. Accessed 29 Mar. 2022.
  11. Lin, Han, et al. “A Systematic Evaluation and Meta-Evaluation of Randomized Placebo-Managed Trials of DHEA Supplementation of Bone Mineral Density in Wholesome Adults.” Gynecological Endocrinology, vol. 35, no. 11, 25 June 2019, pp. 924–931, https://doi.org/10.1080/09513590.2019.1616175. Accessed 7 Dec. 2019.
  12. Villareal, Dennis T., and John O. Holloszy. “Impact of DHEA on Stomach Fats and Insulin Motion in Aged Ladies and Males.” JAMA, vol. 292, no. 18, 10 Nov. 2004, p. 2243, https://doi.org/10.1001/jama.292.18.2243. Accessed 21 Apr. 2020.
  13. Arlt, Wiebke, et al. “Dhea Substitute in Ladies with Adrenal Insufficiency—Pharmacokinetics, Bioconversion and Medical Results on Nicely-Being, Sexuality and Cognition.” Endocrine Analysis, vol. 26, no. 4, Jan. 2000, pp. 505–511, https://doi.org/10.3109/07435800009048561. Accessed 9 Nov. 2019.
  14. Peixoto, C., et al. “The Results of Dehydroepiandrosterone on Sexual Operate: A Systematic Evaluation.” Climacteric: The Journal of the Worldwide Menopause Society, vol. 20, no. 2, 1 Apr. 2017, pp. 129–137, pubmed.ncbi.nlm.nih.gov/28118059/, https://doi.org/10.1080/13697137.2017.1279141. Accessed 18 Feb. 2023.
  15. Morales, A. J., et al. “The Impact of Six Months Remedy with a 100 Mg Day by day Dose of Dehydroepiandrosterone (DHEA) on Circulating Intercourse Steroids, Physique Composition and Muscle Power in Age-Superior Males and Ladies.” Medical Endocrinology, vol. 49, no. 4, Oct. 1998, pp. 421–432, https://doi.org/10.1046/j.1365-2265.1998.00507.x.
  16. Villareal, Dennis T., and John O. Holloszy. “DHEA Enhances Results of Weight Coaching on Muscle Mass and Power in Aged Ladies and Males.” American Journal of Physiology-Endocrinology and Metabolism, vol. 291, no. 5, Nov. 2006, pp. E1003–E1008, https://doi.org/10.1152/ajpendo.00100.2006. Accessed 21 Feb. 2020.
  17. Wolkowitz, Owen M., et al. “Dehydroepiandrosterone (DHEA) Remedy of Despair.” Organic Psychiatry, vol. 41, no. 3, Feb. 1997, pp. 311–318, https://doi.org/10.1016/s0006-3223(96)00043-1. Accessed 12 July 2020.
  18. Genud, Rotem, et al. “DHEA Lessens Depressive-like Habits through GABA-Ergic Modulation of the Mesolimbic System.” Neuropsychopharmacology : Official Publication of the American School of Neuropsychopharmacology, vol. 34, no. 3, Feb. 2009, pp. 577–84, pubmed.ncbi.nlm.nih.gov/18496525/, https://doi.org/10.1038/npp.2008.46.
  19. Rutkowski, Krzysztof, et al. “Dehydroepiandrosterone (DHEA): Hypes and Hopes.” Medicine, vol. 74, no. 11, July 2014, pp. 1195–1207, https://doi.org/10.1007/s40265-014-0259-8.
  20. Li, Yuanyuan, et al. “A Dose-Response and Meta-Evaluation of Dehydroepiandrosterone (DHEA) Supplementation on Testosterone Ranges: Perinatal Prediction of Randomized Medical Trials.” Experimental Gerontology, vol. 141, Nov. 2020, p. 111110, https://doi.org/10.1016/j.exger.2020.111110. Accessed 25 Apr. 2022.
  21. Hu, Ying, et al. “Affect of Dehydroepiandrosterone (DHEA) Supplementation on Testosterone Concentrations and BMI in Aged Ladies: A Meta-Evaluation of Randomized Managed Trials.” Complementary Therapies in Medication, vol. 56, Jan. 2021, p. 102620, pubmed.ncbi.nlm.nih.gov/33220453/, https://doi.org/10.1016/j.ctim.2020.102620.
  22. Arlt, Wiebke, et al. “Biotransformation of Oral Dehydroepiandrosterone in Aged Males: Vital Improve in Circulating Estrogens.” ˜the œJournal of Medical Endocrinology and Metabolism/Journal of Medical Endocrinology & Metabolism, vol. 84, no. 6, 1 June 1999, pp. 2170–2176, https://doi.org/10.1210/jcem.84.6.5789. Accessed 16 June 2024.
  23. von Mühlen, D., et al. “Impact of Dehydroepiandrosterone Supplementation on Bone Mineral Density, Bone Markers, and Physique Composition in Older Adults.” Osteoporosis Worldwide : A Journal Established as Results of Cooperation between the European Basis for Osteoporosis and the Nationwide Osteoporosis Basis of the USA, vol. 19, no. 5, 1 Could 2008, pp. 699–707, www.ncbi.nlm.nih.gov/pmc/articles/PMC2435090/, https://doi.org/10.1007/s00198-007-0520-z. Accessed 25 Aug. 2021.
  24. Barad, David, and Norbert Gleicher. “Impact of Dehydroepiandrosterone on Oocyte and Embryo Yields, Embryo Grade and Cell Quantity in IVF.” Human Replica, vol. 21, no. 11, 22 Sept. 2006, pp. 2845–2849, https://doi.org/10.1093/humrep/del254. Accessed 14 Jan. 2020.
  25. Genazzani, A. R., et al. “Impact of 1-12 months, Low-Dose DHEA Remedy on Climacteric Signs and Feminine Sexuality.” Climacteric, vol. 14, no. 6, 26 Sept. 2011, pp. 661–668, https://doi.org/10.3109/13697137.2011.579649. Accessed 9 June 2022.
  26. Brooke, Antonia M., et al. “Dehydroepiandrosterone Improves Psychological Nicely-Being in Male and Feminine Hypopituitary Sufferers on Upkeep Progress Hormone Substitute.” The Journal of Medical Endocrinology & Metabolism, vol. 91, no. 10, 1 Oct. 2006, pp. 3773–3779, https://doi.org/10.1210/jc.2006-0316. Accessed 24 July 2021.
  27. Labrie, Fernand, et al. “Efficacy of Intravaginal Dehydroepiandrosterone (DHEA) on Reasonable to Extreme Dyspareunia and Vaginal Dryness, Signs of Vulvovaginal Atrophy, and of the Genitourinary Syndrome of Menopause.” Menopause, vol. 23, no. 3, Mar. 2016, pp. 243–256, https://doi.org/10.1097/gme.0000000000000571. Accessed 1 July 2021.



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