Formulator’s Nook #20: Menopause Mind Fog Components

Memo-Q Silk Protein Fibroin Hydrolysate (400mg)

On the coronary heart of our components lies 400mg of Memo-Q, delivering the higher vary of clinically-studied doses for most cognitive influence. Why the utmost dose? Past the truth that that is our dream components, the analysis reveals dose-dependent advantages, with 200-600mg each day offering the best enhancements in reminiscence and focus.

Unprecedented Medical Basis

Memo-Q stands aside with 10 human scientific trials spanning twenty years and all ages group from youngsters to seniors of their 90s. This analysis breadth is just about unmatched within the complement trade, demonstrating constant cognitive advantages throughout various populations.^[2] Whereas our components targets menopausal ladies, the ingredient’s security profile permits flexibility — even a single chocolate sq. (150mg) can profit youthful relations with out concern.

The Acetylcholine Benefit

Memo-Q’s main mechanism includes defending and enhancing acetylcholine availability by way of a number of complementary pathways. Throughout menopause, declining estrogen already compromises cholinergic operate, making acetylcholine preservation essential for sustaining reminiscence and a spotlight.

Analysis demonstrates that Memo-Q helps restore acetylcholine ranges which were depleted by neurotoxic challenges. In preclinical research, when beta-amyloid diminished acetylcholine to simply 45% of regular ranges, therapy with silk protein hydrolysate recovered concentrations to 78-80% of management ranges.^[2] This protecting impact happens with out supplying further choline, suggesting the ingredient works by preserving present neurotransmitter shops somewhat than merely offering constructing blocks.

Moreover, research present that fibroin enzymatic hydrolysate can suppress acetylcholinesterase (AChE) ranges in broken mind tissue, serving to stop the breakdown of this essential reminiscence neurotransmitter.^[3] This twin strategy of defending present acetylcholine whereas lowering its enzymatic breakdown creates a strong basis for cognitive enhancement.

By preserving present acetylcholine whereas our different components help new synthesis, Memo-Q creates a dual-action strategy that instantly addresses the reminiscence lapses and a spotlight deficits that characterize menopausal mind fog. This safety of the cholinergic system gives sustained cognitive help all through the difficult hormonal transition of menopause.

Memo-Q breaks the mould in cognitive enhancement. This silk protein-derived ingredient from Freemen Nutra has 10 human scientific trials displaying reminiscence and studying advantages throughout ALL ages — from 7-year-olds to 90+ seniors. 4 mechanisms, one highly effective ingredient. 400-600mg each day.

BDNF Stimulation: Constructing Cognitive Resilience

Past neurotransmitter modulation, Memo-Q considerably will increase Mind-Derived Neurotrophic Issue (BDNF) expression in hippocampal tissue.^[4] This progress issue is essential for neuroplasticity — the mind’s potential to kind new connections and adapt to altering hormonal environments.

BDNF prompts a number of essential pathways for neuronal survival and progress, serving to to transform short-term reminiscences into long-term ones.^[4] Analysis reveals that amyloid beta suppresses BDNF expression, however Memo-Q counteracts that suppression, sustaining wholesome BDNF ranges even within the presence of neurotoxic challenges.

For menopausal ladies, enhanced BDNF means higher adaptation to estrogen decline, improved reminiscence consolidation, and safety in opposition to age-related cognitive decline. The neuroplasticity advantages prolong past reminiscence: BDNF promotes the technology of new neurons and synapses whereas defending present ones from dying. With each neurogenesis and neuroprotection from improved BDNF, Memo-Q creates an surroundings the place the mind can keep cognitive flexibility, adapt to new challenges, and protect operate regardless of ageing or stress.

The 400mg dose ensures sturdy BDNF stimulation primarily based on the dose-response relationships noticed in analysis, offering the muse for sustained cognitive enhancement all through the hormonal transition of menopause.

Enhanced Cerebral Blood Movement

Memo-Q addresses one other essential part of mind fog: compromised blood move to cognitive facilities. Medical analysis utilizing mind imaging demonstrates important will increase in cerebral perfusion to mind areas essential for reminiscence formation and retrieval.^[5] Individuals confirmed measurable will increase in blood move alongside cognitive enhancements, with imply IQ scores growing from 103 to 114 after three weeks of supplementation.

This silk protein-derived nootropic claims the highest spot for reminiscence analysis, focusing on 4 key areas of mind operate you need to optimize.

Enhanced cerebral circulation delivers extra oxygen and glucose to energetic neurons whereas effectively eradicating metabolic waste merchandise. This improved vascular operate instantly counters the circulation adjustments that may accompany menopause, supporting sustained psychological vitality all through the day.

Neuroprotection and Antioxidant Protection

Memo-Q gives neuroprotective advantages by way of a number of complementary mechanisms. Analysis demonstrates safety in opposition to a big array of neurotoxic challenges, starting from toxicities to hazardous mineral complexes to surgically-induced insults.^[6]

When challenged with amyloid beta (the protein that varieties poisonous plaques related to neurodegeneration), Memo-Q considerably diminished pro-inflammatory cytokines in mind hippocampal tissue.^[4] Equally, when neurons had been challenged with scopolamine (which blocks acetylcholine receptors and induces reminiscence impairment), Memo-Q therapy considerably diminished the identical inflammatory markers.^[3]

This multi-target neuroprotection seems to work by way of a number of mechanisms concurrently. Memo-Q maintains mitochondrial operate beneath oxidative stress, preserves mobile vitality manufacturing, and prevents the buildup of reactive oxygen species that harm neuronal membranes and DNA.

This diagram reveals how silk fibroin will get enzymatically damaged down into the bioactive peptides that energy your cognitive enhancement.

The Peptide Benefit

What makes Memo-Q uniquely efficient is its supply: enzymatically hydrolyzed fibroin creates bioactive peptides that effectively cross the blood-brain barrier and stay steady within the bloodstream. Not like artificial compounds or poorly absorbed plant extracts, these silk-derived peptides work by way of a number of pathways concurrently: acetylcholine enhancement, BDNF stimulation, neuroprotection, and vascular help as talked about above.

Metabolic Synergy

Analysis reveals an sudden profit: Memo-Q enhances glucose metabolism and insulin sensitivity.^[7][8] This metabolic help not solely gives neurons with the vitality wanted for demanding cognitive duties however creates excellent synergy with our chocolate supply system. Enhanced glucose uptake helps optimize the pure temper and vitality advantages from cocoa whereas supporting sustained cognitive efficiency.

At 100mg per chocolate sq., you could possibly max dose as much as 6 squares, however 3-4 squares can be optimum when it comes to value and efficiency.

You possibly can study extra in our article titled “Memo-Q: The Silk Protein From Freemen Nutra That is Revolutionizing Cognitive Enhancement“.

effera™ Human Lactoferrin (200mg): Precision-Engineered Iron Intelligence

The inclusion of 200mg effera™ addresses a essential but neglected side of menopausal cognitive well being: iron dysregulation and irritation. This is not your typical lactoferrin complement, both: effera™ represents a breakthrough in precision fermentation expertise, creating the world’s first commercially accessible human-identical lactoferrin.

The Estrogen-Lactoferrin Connection

Here is what most formulators miss: lactoferrin manufacturing is estrogen-mediated.^[9] As estrogen declines throughout menopause, endogenous lactoferrin manufacturing plummets dramatically, making a double deficit that contributes to each fatigue and cognitive dysfunction. This hormonal connection explains why so many menopausal ladies expertise unexplained vitality crashes and mind fog regardless of seemingly ample diet.

Ten human trials spanning ages 7 to 94 reveal Memo-Q’s broad applicability throughout various populations.

effera™ compensates for this estrogen-related decline whereas avoiding the immune issues that plague bovine lactoferrin supplementation. The human-identical construction ensures the physique acknowledges it as “self”, stopping the inflammatory cascade that may happen with international proteins.

Medical Superiority: Human vs. Bovine

Essentially the most highly effective proof for effera™’s benefits comes from head-to-head scientific research. In a randomized, double-blind managed trial, contributors taking bovine lactoferrin developed antibodies in opposition to the protein, indicating their immune programs had been actively making an attempt to clear it as a international substance.^[10]

In stark distinction, contributors taking effera™ confirmed zero antibody growth at any dose degree, demonstrating that the physique accepts it as native human protein! This discovering has profound implications: if the immune system is actively clearing bovine lactoferrin, it can not stay in circulation lengthy sufficient to offer optimum advantages.

Moreover, effera™ digests identically to native human lactoferrin, breaking down into the identical bioactive peptides that present particular well being advantages. Bovine lactoferrin digests in a different way, producing totally different peptide fragments that will not ship the identical therapeutic results. This ingredient is the long run, and it is right here in the present day.

Superior Iron Regulation

As we discovered in our podcast interviews with Helaina’s crew (Episodes #167 and #180), effera™ demonstrates subtle iron administration by way of a number of key mechanisms:

• Twin iron-binding websites that act like “organic magnets”, grabbing iron with extraordinary affinity and responding to native tissue wants
• “Clever” distribution that helps each iron-deficient and iron-overloaded people by modulating availability somewhat than merely including extra iron
• Anemia of irritation help – addresses the foundation trigger when ample iron exists however is not being delivered the place wanted (affecting over 80% of pregnant ladies and more and more acknowledged in perimenopausal ladies)
• Enhanced iron transport from tissues into circulation the place it is really wanted, explaining why ladies report improved vitality even with “regular” iron research

20 years of analysis backing Memo-Q units it aside from typical nootropics that depend on just some research.

This strategy makes effera™ a substitute for conventional iron dietary supplements, serving to regulate iron ranges somewhat than merely flooding the system with extra iron.

Bone Well being Synergy

Past cognitive advantages, effera™ gives focused help for postmenopausal bone well being. Analysis demonstrates important enhancements in bone turnover markers in postmenopausal ladies, with lactoferrin serving to to protect bone homeostasis.^[11] That is particularly related for the ageing feminine demographic.

Synergy with Memo-Q

The mixture of effera™ and Memo-Q creates highly effective synergistic results:

• Complementary anti-inflammatory pathways – effera™’s “dampening of irritation manyfold bigger” than bovine lactoferrin completely enhances Memo-Q’s neuroprotective results
• Enhanced mobile vitality – optimum iron supply helps the elevated glucose metabolism and mitochondrial operate promoted by Memo-Q
• BDNF amplification – each components help neuroplasticity by way of totally different however complementary mechanisms
• Vascular optimization – improved iron transport enhances the cerebral blood move advantages demonstrated with Memo-Q

You are getting mind help by way of acetylcholine enhancement, BDNF stimulation, neuroprotection, and improved blood move — all from Memo-Q.

The 200mg dose gives clinically significant help primarily based on research demonstrating improved hemoglobin ranges and iron parameters in ladies throughout all life levels, from being pregnant by way of menopause.^[12]

GeniusPure® Alpha-GPC 90% (235mg): The Subsequent-Technology Choline Supply

With 235mg of GeniusPure® delivering 90% alpha-GPC, our components gives a strategic dose optimized for each each day cognitive help and potential acute results should you had been to splurge. Whereas most alpha-GPC merchandise usually ship 50% yield and undergo from stability points, GeniusPure’s superior manufacturing achieves 90% purity with superior shelf-life traits.^[13] This ensures constant efficiency all through our chocolate’s shelf life whereas maximizing the energetic compound supply in every sq..

Twin-Pathway Acetylcholine Enhancement

Alpha-GPC gives distinctive benefits over fundamental choline dietary supplements by way of its dual-mechanism strategy. Upon absorption, GeniusPure® converts to each phosphorylcholine and free choline, creating a number of pathways for acetylcholine synthesis.^[14] This twin substrate supply ensures sturdy acetylcholine help that works synergistically with Memo-Q’s acetylcholine preservation results.

Analysis demonstrates that alpha-GPC considerably will increase acetylcholine launch within the hippocampus, the mind area most crucial for reminiscence formation and retrieval.^[15] Not like easy choline salts that present restricted mind penetration, alpha-GPC effectively crosses the blood-brain barrier and instantly helps neuronal membrane synthesis.

Memo-Q supplementation helps you bear in mind considerably extra phrases on each preliminary studying and after repetition, with 400mg displaying optimum first-trial efficiency.^[16]

Past Neurotransmitters: Complete Mind Assist

The compound additionally contributes to membrane phospholipid synthesis, positively influencing neuron membranes and structural integrity.^[14] Throughout menopause, when estrogen’s neuroprotective results decline, sustaining wholesome membrane composition turns into essential for optimum mind operate.

Alpha-GPC additionally will increase dopamine and serotonin ranges in mind areas essential for motivation and temper regulation.^[17] A research particularly inspecting motivation discovered that wholesome volunteers taking 400mg alpha-GPC each day confirmed important enhancements in motivation ranges, with results most pronounced within the night hours.^[17]

Why 235mg? Acute Assist at Six Goodies!

Within the opening sentence, we teased acute advantages should you had been to splurge. Why 235mg in 4 sweets? Moreover the truth that it is extra inexpensive and extra simply matches into the shape issue, it ensures that ladies taking six chocolate squares would attain the clinically-studied 350mg dose demonstrated to ship acute cognitive advantages!^[13]

In that randomized, double-blind, placebo-controlled crossover trial, contributors taking a yield of 315mg alpha-GPC (equal to a 350mg GeniusPure® 90% dose) confirmed outstanding enhancements in cognitive efficiency.^[13]

The outcomes had been placing: 108% enchancment in Stroop take a look at efficiency and 50% enhance in processing velocity in comparison with placebo, with results showing inside 60 minutes of administration.^[13] These cognitive assessments particularly measure selective consideration, cognitive flexibility, and data processing — exactly the psychological features that decline throughout menopausal mind fog.

Memo-Q improves your potential to recall data after delays, although the impact plateaus round 400mg each day.^[16]

Good Synergy with Our Components

The 235mg GeniusPure® dose creates highly effective synergy with our different components:

• Enhances Memo-Q’s acetylcholine preservation with contemporary acetylcholine synthesis
• Enhances B-vitamin methylation help by way of improved choline availability
• Helps mobile vitality manufacturing alongside magnesium and niacin

This ensures that ladies experiencing menopausal mind fog obtain each quick cognitive enhancement and long-term neurological help, making our purposeful chocolate a whole resolution for sustaining psychological sharpness throughout this difficult transition.

So it is a dose that is not too little, not an excessive amount of, and permits maximum-strength dosing of each Memo-Q and GeniusPure collectively in six sweets.

Xeya® Shatavari (50mg): The Queen of Ayurveda Meets Trendy Science

Shatavari (Asparagus racemosus), referred to as the “Queen of Ayurveda”, has been treasured for hundreds of years as a main feminine reproductive tonic.^[18] This adaptogenic herb historically helps hormonal steadiness all through a girl’s life levels (from menstruation by way of menopause), making it an ideal complement to our Memo-Q-centered cognitive components.

Breakthrough Medical Proof

The scientific validation of shatavari has reached new heights with latest groundbreaking analysis. A newly printed randomized, double-blind, placebo-controlled trial demonstrated outstanding efficacy of NXT-USA’s standardized shatavari extract, Xeya® Shatavari, in perimenopausal ladies.^[19]

Each 400mg and 600mg doses of Memo-Q ship statistically important enhancements in how properly you keep discovered data.^[16]

Over 120 days, ladies taking 50mg each day of this 15% shatavarin-standardized extract skilled a 51% discount in Menopausal Score Scale scores, with even higher advantages at 100mg (73% discount). Sizzling flash severity decreased by 28% on the decrease dose, whereas menstrual signs confirmed marked enchancment throughout a number of domains.^[19]

Most spectacular had been the hormonal adjustments: FSH ranges dropped 52%, LH decreased 30%, whereas anti-Müllerian hormone (AMH) (a key marker of ovarian reserve) elevated by 125% on the 50mg dose. Ovarian follicle counts elevated by 34%, suggesting real enchancment in reproductive operate somewhat than mere symptom masking.^[19]

Mechanisms of Hormonal Assist

Shatavarins, the important thing bioactive compounds in shatavari, are steroidal saponins with demonstrated affinity for estrogen receptors.^[20] Molecular docking research reveal that a number of shatavarin compounds work together with estrogen alpha, beta, and gamma receptors, in addition to progesterone, FSH, and LH receptors,^[20] that means there are hormonal modulatory results that would assist stabilize the fluctuations contributing to mind fog and different menopausal signs.^[21]

The scientific research reveals shatavari’s twin regulatory mechanism: it seems to normalize hypothalamic-pituitary-gonadal axis homeostasis by way of enhanced adverse suggestions whereas supporting ovarian folliculogenesis and steroidogenesis. This bidirectional adaptogenic exercise explains why it will probably concurrently scale back elevated gonadotropins whereas supporting ovarian operate.^[19]

Analysis additionally reveals shatavari could present further well being advantages by way of improved muscle operate. A research in postmenopausal ladies discovered eight weeks of shatavari supplementation mixed with resistance coaching elevated handgrip power and enhanced muscle protein regulation.^[22] This bodily power part could translate to raised general vitality throughout the cognitively demanding menopausal transition.

Memo-Q delivers clear dose-dependent enhancements in reminiscence operate, with the best 600mg dose delivering almost 25-point features over placebo.^[16]

Xeya®: Subsequent-Technology Shatavari from NXT-USA

For our components, we have chosen Xeya® Trendy Shatavari from NXT-USA at 50mg each day in 4 sweets, which is a breakthrough in shatavari expertise. Conventional shatavari extracts usually require 500-1000mg doses, however Xeya’s superior standardization to 15% shatavarins permits efficient dosing at simply one-tenth the everyday quantity.

In line with NXT-USA, Xeya® is “twice as efficient at one-fifth the dose” in comparison with typical shatavari extracts. This efficiency benefit makes it excellent for our chocolate format whereas making certain clinically significant hormonal help. Most significantly, Xeya was used within the groundbreaking perimenopausal research talked about above.^[19]

Whereas one other research on PCOS stays pending publication, the printed perimenopausal analysis gives compelling proof for Xeya’s efficacy at this 50mg dose.^[19]

Past Hormones: Different Wellness Advantages (Pores and skin High quality)

The scientific trial revealed advantages extending past hormonal steadiness. Individuals noticed important enhancements in pores and skin high quality, with zits severity scores declining 46% and perceived pores and skin high quality growing 99%.^[19] Hair high quality parameters confirmed equally spectacular enhancements: 100% discount in hair fall, 121% enchancment in texture, and 162% enhance in quantity.

The inclusion of Xeya® alongside Memo-Q transforms our components from purely cognitive help into a really well-rounded strategy addressing each the neurological and hormonal points of menopausal mind fog, with some skincare advantages as well. NXT-USA seems to be to have established Xeya® as the brand new benchmark for shatavari supplementation.

Strategic Mineral Assist

Memo-Q helps you study materials extra effectively at larger doses, although the enhancements degree off as you enhance from 400mg to 600mg each day.^[16]

• Iron Bisglycinate (4mg, 50% DV)

  Past effera™’s subtle iron regulation lies an important however underappreciated reality: iron deficiency instantly impairs cognitive operate, even in in any other case wholesome adults.

  The Iron-Cognition Connection: Hidden Mechanisms Behind Mind Fog

  Analysis demonstrates that iron-deficient ladies present important deficits in consideration, reminiscence, and studying, and these are deficits that normalize following restoration of iron standing.^[23]

  Neurotransmitter Synthesis Disruption

  Iron serves as a necessary cofactor for the rate-limiting enzymes in dopamine and serotonin synthesis.^[24] When iron shops decline, neurotransmitter manufacturing falters. This explains why iron-deficient ladies report the precise signs we see in menopause: issue concentrating, psychological fatigue, and temper adjustments.

  Analysis reveals iron deficiency decreases dopamine receptors in mind areas essential for consideration and government operate.^[23] The dopaminergic system strongly correlates with cognitive efficiency all through the grownup lifespan, making iron optimization essential for sustaining psychological acuity throughout menopause.

  Mobile Power Metabolism

  Iron deficiency compromises elementary mobile bioenergetics for mitochondrial ATP manufacturing. The mind areas most affected, the hippocampus and frontal cortex, are additionally these concerned in reminiscence formation and government operate.^[24] The mixture of some iron with effera™’s clever iron supply ensures these energy-demanding cognitive facilities obtain ample iron for optimum mitochondrial operate, in order that nothing holds Memo-Q’s potential advantages again.

• Zinc Picolinate (8mg, 73% DV)

  

  Memo-Q enhances visuospatial reminiscence duties in a dose-dependent method, with 600mg delivering the strongest features in advanced sample recall.^[16]

  Zinc picolinate at an 8mg yield of zinc gives significant help for cognitive and hormonal pathways essential throughout menopause. Analysis reveals zinc picolinate demonstrates superior bioavailability in comparison with different zinc varieties, with important will increase in hair, urine, and pink blood cell zinc ranges.^[25]

  For menopausal ladies, zinc gives multifaceted advantages:^[26]

  • Hormone regulation help: Zinc modulates estrogen receptor exercise and helps wholesome testosterone ranges, serving to steadiness the hormonal fluctuations that contribute to mind fog.
  • Antioxidant protection: As a cofactor for superoxide dismutase, zinc gives essential safety in opposition to oxidative stress that will increase throughout menopause. This antioxidant exercise works synergistically with Memo-Q’s neuroprotective results.
  • Neurotransmitter synthesis: Zinc serves as a cofactor for enzymes concerned in dopamine, serotonin, and GABA manufacturing — neurotransmitters usually imbalanced throughout menopause.
  • Immune system help: Declining estrogen compromises immune operate, whereas zinc helps keep sturdy immune response and reduces inflammatory markers that may contribute to mind fog.
  • Sleep high quality enhancement: Analysis reveals zinc supplementation improves sleep onset and high quality, addressing one other frequent menopause criticism that instantly impacts cognitive operate.

• Magnesium Glycinate (Yielding 50mg, 12% DV)

  Whereas house constraints restrict us to 50mg elemental magnesium from glycinate, this quantity nonetheless gives significant advantages. The glycinate kind affords superior absorption and the additional benefit of glycine for neurotransmitter help.^[27]

  

  Not like single-pathway nootropics, you are getting complete mind help by way of Memo-Q’s 4 distinct organic mechanisms.

  Even at this dose, magnesium glycinate contributes to:^[28]

  • NMDA receptor modulation for cognitive operate
  • Sleep high quality help addressing a typical menopause criticism
  • Stress response regulation by way of HPA axis modulation

  Be aware for formulators: If making a powder or bigger serving dimension, contemplate growing to 100-200mg for extra sturdy results. We are able to solely match a lot right into a chocolate, as magnesium glycinate has solely a ten% magnesium yield.

The B-Vitamin Trinity: Folate, B12, and Niacin

• Folinic Acid (400mcg DFE, 100% DV)

  For our folate supply, we have chosen folinic acid over folic acid for superior bioavailability and quick metabolic availability. Not like folic acid, folinic acid bypasses the DHFR enzyme bottleneck that creates delays and potential accumulation, which is essential for the 40% of ladies with MTHFR polymorphisms that compromise folate metabolism.^[29]

  Direct Neurotransmitter Assist

  Folinic acid instantly helps the methylation pathways important for neurotransmitter synthesis: dopamine, serotonin, and norepinephrine manufacturing all require ample folate cofactors.^[30] Throughout menopause, declining estrogen disrupts these similar pathways, making optimum folate standing essential for sustaining temper stability and cognitive readability. This energetic kind ensures quick availability for methylation reactions with out metabolic conversion delays.

  

  You may see spectacular double-digit enhancements throughout reminiscence, studying, and focus assessments if you complement with Memo-Q.

  Homocysteine Regulation and Mind Well being

  The 400mcg dose gives help for homocysteine metabolism, working synergistically with methylcobalamin to stop the elevation that generally happens throughout menopause. Elevated homocysteine instantly impairs cognitive operate and will increase cardiovascular threat — two main issues for ladies on this demographic. Analysis demonstrates folinic acid’s superior efficacy in lowering homocysteine ranges in comparison with folic acid, whereas avoiding the unmetabolized folic acid syndrome that may intrude with pure folate utilization.^[30]

  That is the folate supply extra ladies have to find out about.

• Methylcobalamin (6mcg, 250% DV)

  Methylcobalamin at 6mcg gives B12 help in its most bioactive kind, addressing a number of pathways that generally decline throughout menopause. This energetic coenzyme kind bypasses the mobile conversion steps required by cyanocobalamin, making certain quick metabolic availability.^[31]

  B12 deficiency impacts as much as 40% of adults over 60, making supplementation essential throughout menopause when absorption naturally declines.^[32] The vitamin serves as a necessary cofactor in sustaining wholesome homocysteine ranges and supporting mobile vitality manufacturing.

  Most significantly, B12 performs a elementary position in neurotransmitter synthesis and neuronal structural upkeep.^[32] Medical analysis in middle-aged and aged adults with cognitive impairment confirmed that B12 supplementation considerably improved consideration, calculation, and visuospatial operate, that are the identical cognitive domains affected by menopausal mind fog.^[32] This way works synergistically with folinic acid to optimize methylation pathways important for cognitive operate, stopping the “folate lure” that may happen with insufficient B12 standing.

• Niacin as Nicotinic Acid (12mg, 75% DV)

  

  You may discover Memo-Q in every part from conventional capsules to purposeful meals and ready-to-drink drinks.

  A strategic 12mg of nicotinic acid gives sturdy NAD+ help whereas staying comfortably under flushing thresholds. This dose delivers significant cognitive and metabolic advantages with out the vasodilation results that usually start round 50mg.^[33]

  NAD+ and Mobile Power Manufacturing

  Niacin serves because the precursor to NAD+ (nicotinamide adenine dinucleotide), a essential coenzyme concerned in over 400 enzymatic reactions all through the physique.^[34] Throughout menopause, declining mobile vitality manufacturing contributes considerably to mind fog and psychological fatigue.

  By supporting NAD+ synthesis, nicotinic acid instantly enhances mitochondrial operate in energy-demanding mind areas just like the hippocampus and frontal cortex: areas essential for reminiscence formation and government operate.^[34] Analysis demonstrates that optimum NAD+ ranges assist restore mitochondrial operate and counteract cognitive decline related to ageing and hormonal adjustments.

  Cerebral Blood Movement Enhancement

  Nicotinic acid promotes vasodilation particularly in cerebral vessels, growing blood move to cognitive facilities.^[34] This enhanced cerebral circulation delivers extra oxygen and glucose to energetic neurons whereas effectively eradicating metabolic waste merchandise, instantly addressing the circulation adjustments that may accompany menopause and contribute to psychological sluggishness.

  Research present that niacin will increase native cerebral blood move.^[34] This vascular help creates excellent synergy with Memo-Q’s personal cerebral blood move advantages, amplifying the general cognitive enhancement impact.