With regards to anti-aging skincare, there are a few tried-and-true injectables. Hyaluronic acid fillers and Botox are the 2 most typical. Nevertheless, a brand new standard remedy is rising for pores and skin rejuvenation. Polynucleotide injections have gotten more and more standard for hydration, anti-aging, and pores and skin restore. Polynucleotide injections are beginning to be mentioned interchangeably with hyaluronic acid fillers, however they work in very other ways. So, how do you select the appropriate one to your pores and skin? Let’s break it down.
What Are Hyaluronic Acid Fillers and Polynucleotide Injections?
What Is a Hyaluronic Acid Remedy?
Hyaluronic acid is a naturally occurring sugar discovered within the pores and skin. It helps retain moisture and provides pores and skin cells a spot to develop. Hyaluronic acid fillers are often known as dermal fillers. Dermal fillers work by including quantity, plumping wrinkles, and deeply hydrating the pores and skin. The are extra everlasting, however they provide an prompt plumping impact. In distinction, polynucleotide injections, which give attention to cell regeneration.
What Is a Polynucleotide Remedy?
Polynucleotides are DNA fragments. Particularly in skincare, they’re derived from fish, normally salmon. For this reason polynucleotide injections are generally referred to as salmon sperm facials. They’re used to assist stimulate pores and skin restore, collagen manufacturing, and hydration. When injected into the pores and skin, they enhance mobile renewal, enhance elasticity, and cut back redness and irritation. Polynucleotides are recognized for his or her biostimulatory results. This implies they encourage the pores and skin to heal and restore itself over time.
Key Variations Between Polynucleotides and Hyaluronic Acid
The only option will depend on your pores and skin wants. Let’s take a more in-depth have a look at which remedy works greatest for various considerations.
| Function | Polynucleotides Injectison (PN) | Hyaluronic Acid (HA) |
|---|---|---|
| Important Operate | Pores and skin restore & collagen stimulation | Hydration & quantity enhancement |
| How It Works | Stimulates cell regeneration & therapeutic | Fills and hydrates the pores and skin immediately |
| Finest For | Wonderful traces, pores and skin texture, elasticity, redness | Deep wrinkles, quantity loss, intense hydration |
| Outcomes Timeline | Gradual (seen after a number of weeks) | Instant plumping impact |
| Longevity | 6+ months with upkeep | 6-12 months, relying on the kind of filler |
| Remedy Areas | Face, neck, palms, scalp, stretch marks | Lips, cheeks, beneath eyes, jawline, deep wrinkles |
| Facet Results | Delicate swelling, redness, bruising | Swelling, bruising, danger of lumps or migration |
| Finest Candidates | These in search of pores and skin regeneration & anti-inflammatory advantages | These wanting prompt hydration or quantity restoration |
Can Polynucleotides and Hyaluronic Acid Be Mixed?
Sure! Hyaluronic acid fillers and polynucleotide injections can be utilized collectively. In actual fact, a survey given to over 200 dermatologists who use polynucleotide injections of their observe confirmed that they used them with different therapies like hyaluronic acid fillers. Some research present that utilizing polynucleotides earlier than HA fillers can enhance and lengthen the outcomes.
Facet Results and Security: Polynucleotide Injections vs. Hyaluronic Acid Fillers
Each therapies are protected and customarily well-tolerated. Nevertheless, they’ve totally different unwanted side effects. Each may cause some swelling and bruising. If you’re allergic to fish, polynucleotide injections may cause an allergic response. Hyaluronic acid fillers may cause filler migration, unevenness, and blood vessel blockages if not injected accurately. No matter danger, each therapies ought to all the time be carried out by a licensed skilled.
How A lot Do Polynucleotide Injections and Hyaluronic Acid Fillers Value?
The price will depend on the place you reside and who does the remedy. It additionally will depend on how a lot product is used. Polynucleotide injections normally price $300–$800 per session (3-4 periods). Hyaluronic acid fillers price $500–$1,500 per syringe (1-2 syringes per space). Polynucleotide injections might sound cheaper per session. However you want extra periods. Hyaluronic fillers price extra per syringe. However they provide you quick outcomes with fewer periods. No matter your remedy, you don’t wish to search the most affordable supplier. It’s best to solely get therapies carried out by a trusted and licensed skincare skilled.
Remaining Verdict: Which One Ought to You Select?
| If You Need… | Select |
|---|---|
| Instant hydration & plumping | Hyaluronic Acid |
| Lengthy-term pores and skin restore & anti-aging | Polynucleotides |
| Wonderful line & wrinkle discount | Each (PN for texture, HA for deep wrinkles) |
| Improved elasticity & collagen enhance | Polynucleotides |
| Quantity restoration (cheeks, lips, beneath eyes) | Hyaluronic Acid |
| Redness & delicate pores and skin aid | Polynucleotides |
| A mixture strategy for greatest outcomes | Each! (PN first, then HA) |
For quick outcomes, hyaluronic acid fillers are higher. If you’re in search of long-term pores and skin enchancment, polynucleotide injections may help. For the most effective outcomes, use each. Discuss to a pores and skin skilled. They will let you know what’s greatest to your pores and skin!
References
Araco A, Araco F, Raichi M. Medical efficacy and security of polynucleotides extremely purified know-how (PN-HPT®) and cross-linked hyaluronic acid for average to extreme nasolabial folds: A potential, randomized, exploratory research. J Cosmet Dermatol. 2023 Jan;22(1):146-155. doi: 10.1111/jocd.15064. Epub 2022 Might 26. PMID: 35531796; PMCID: PMC10084116.
Cavallini M, Bartoletti E, Maioli L, Massirone A, Pia Palmieri I, Papagni M, Priori M, Trocchi G; As Members of The Polynucleotides HPT™ Priming Board, Collegio Italiano delle Società Scientifiche di Medicina Estetica (Italian Faculty of the Aesthetic Medication Scientific Societies) – SIME, AGORÀ, SIES. Consensus report on the usage of PN-HPT™ (polynucleotides extremely purified know-how) in aesthetic medication. J Cosmet Dermatol. 2021 Mar;20(3):922-928. doi: 10.1111/jocd.13679. Epub 2020 Sep 21. PMID: 32799391; PMCID: PMC7984045.
Lampridou S, Bassett S, Cavallini M, Christopoulos G. The Effectiveness of Polynucleotides in Esthetic Medication: A Systematic Evaluate. J Cosmet Dermatol. 2024 Dec 8:e16721. doi: 10.1111/jocd.16721. Epub forward of print. PMID: 39645667.
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Lee D, Kim MJ, Park HJ, Rah GC, Choi H, Anh ST, Ji GH, Kim MS, Kim G, Shin DW, Oh SM. Present practices and perceived effectiveness of polynucleotides for remedy of facial erythema by beauty physicians. Pores and skin Res Technol. 2023 Sep;29(9):e13466. doi: 10.1111/srt.13466. PMID: 37753681; PMCID: PMC10485387.
Lee KWA, Chan KWL, Lee A, Lee CH, Wan J, Wong S, Yi KH. Polynucleotides in Aesthetic Medication: A Evaluate of Present Practices and Perceived Effectiveness. Int J Mol Sci. 2024 Jul 27;25(15):8224. doi: 10.3390/ijms25158224. PMID: 39125793; PMCID: PMC11311621.
Lim TS, Liew S, Tee XJ, Chong I, Lo FJ, Ho MJ, Ong Ok, Cavallini M. Polynucleotides HPT for Asian Pores and skin Regeneration and Rejuvenation. Clin Cosmet Investig Dermatol. 2024 Feb 13;17:417-431. doi: 10.2147/CCID.S437942. PMID: 38371328; PMCID: PMC10874187.
Park KY, Seok J, Rho NK, Kim BJ, Kim MN. Lengthy-chain polynucleotide filler for pores and skin rejuvenation: efficacy and issues in 5 sufferers. Dermatol Ther. 2016 Jan-Feb;29(1):37-40. doi: 10.1111/dth.12299. Epub 2015 Nov 2. PMID: 26814448.
Rho NK, Han KH, Cho M, Kim HS. A survey on the beauty use of injectable polynucleotide: The sample of observe amongst Korean Dermatologists. J Cosmet Dermatol. 2024 Apr;23(4):1243-1252. doi: 10.1111/jocd.16125. Epub 2023 Dec 13. PMID: 38093498.
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