Science-Primarily based Focus & Productiveness Line Loaded with Cognizin Citicoline

Neutonic brings research-backed nootropics with medical 500mg Cognizin doses in 3 kinds. See how James Smith & Chris Williamson partnered with Kyowa Hakko to create respectable cognitive enhancement dietary supplements.

In an trade full of flashy advertising and underdosed formulation, Neutonic enters the nootropic complement area with a refreshingly totally different method: research-backed substances at clinically-validated doses, led by the premier type of citicoline, Cognizin® — out there in three totally different kind elements.

James Smith & Chris Williamson: The Founders Behind the Focus

James Smith and Chris Williamson, two well-known British content material creators and entrepreneurs, spent over a 12 months creating Neutonic’s product line. Their mission wasn’t simply to create one other vitality drink – it was to formulate respectable cognitive-enhancement dietary supplements that might assist their very own high-performance existence whereas sustaining scientific validity.

To attain this purpose, they partnered with the model builders at GenFlow, then introduced within the scientific minds at Kyowa Hakko, builders of Cognizin® citicoline, to create three distinctive supply codecs:

• Neutonic Productiveness Drink – A zero-sugar vitality drink different offering 500mg Cognizin alongside 120mg pure caffeine and research-backed adaptogens
• Neutonic Focus Mix – Caffeine-free powder stick packs with the identical medical Cognizin dose plus nootropic assist
• Neutonic Mind Capsules – A complete day by day complement that includes further cognitive-supporting substances like Bacopa monnieri and Ginkgo biloba

Every product incorporates a full 500mg dose of Cognizin® citicoline, demonstrating Neutonic’s dedication to efficacy over revenue margins. This dedication to science-based formulation units them aside in an more and more crowded complement class.

Join PricePlow’s Neutonic information alerts to get notified of latest product launches, offers, and taste releases:

You can even join PricePlow’s Cognizin and Kyowa Hakko information, after which proceed studying to be taught extra about Cognizin citicoline and the way every Neutonic product can assist your cognitive efficiency wants.

The Science Behind Cognizin® Citicoline

Citicoline (CDP-choline) is a naturally-occurring compound that serves as each a supply of choline and a important intermediate within the synthesis of phosphatidylcholine, a serious element of mind cell membranes.^[1] Made by Kyowa Hakko, Cognizin® is the trade’s premiere type of citicoline.

When supplemented orally, citicoline is damaged down into choline and cytidine within the intestine, with the cytidine later changing to uridine. These compounds cross the blood-brain barrier the place they’re reassembled into CDP-choline, offering the mind with important constructing blocks for neurotransmitter and phospholipid synthesis.^[2]

It is a type of choline that may be felt — analysis has demonstrated that citicoline supplementation enhances frontal lobe bioenergetics and alters phospholipid membrane turnover. Utilizing superior mind imaging strategies, researchers discovered that 500mg of Cognizin per day led to important will increase in mind phosphocreatine (+7%) and beta-nucleoside triphosphates (+14%), indicating improved mobile vitality standing.^[3]

Finally, when taken day by day, Cognizin® helps long-term mind well being,^[3,4] however let’s dive deeper into the analysis under.

Typically talking, Cognizin® helps mind and cognitive well being^[4-9] because it gives day by day assist for mind well being^[3,4] and helps wholesome mind cell signaling, mind DNA synthesis, and restore.^[1,2,10] It helps keep wholesome neurotransmitter ranges, supporting acetylcholine, dopamine, and norepinephrine ranges.^[1]

Getting extra particular, Medical analysis helps varied cognitive advantages at each 250mg and 500mg day by day doses, and with 500mg in Neutonic, there’s a lot to speak about right here!

Cognizin® Citicoline is dubbed the The Mind Choline not simply because it gives choline, however as a result of it additionally provides cytidine, which can be wanted for the synthesis of phosphatidylcholine

At 250mg per day:

• Accuracy, Focus & Consideration, and Productiveness: At 250mg per day, Cognizin® helps enhance accuracy and scale back errors whereas on activity.^[5,6,11] It helps assist focus whereas serving to to enhance focus and a focus,^[3,5,6] and helps your potential to keep centered, supporting staying on activity.^[3,5,6]

  Productiveness positive aspects may be made as Cognizin® helps assist productiveness by focus, response time, and accuracy^[3,5-7,11]

• Phospholipids: Mechanically talking, Cognizin® helps phosphatidylcholine manufacturing and phospholipid metabolism within the mind^[1,3,12]

At 500mg per day:

• Psychological Power, Psychomotor Efficiency, and Reminiscence: Cognizin® helps psychological vitality and vitality utilization within the mind,^[3,12] in addition to motor velocity and performance, psychological processing velocity, and serving to to enhance response time whereas aiding in receiving and processing info.^[6,7,11]

  A number of research have proven that Cognizin® additionally helps assist reminiscence and wholesome reminiscence processes, together with working reminiscence, working reminiscence recall, and episodic reminiscence.^{[3,4,7-9,11-13]}

• Oxidative stress (500mg/day) Past the above endpoints, Cognizin® additionally helps mobile well being, wholesome antioxidant exercise / wholesome antioxidant protection mechanisms, and has antioxidant results by reducing malondialdehyde (MDA),^[7] a really poisonous aldehyde waste product created when metabolizing toxins.

Past the analysis, Cognizin® stands aside because the premier type of citicoline attributable to its in depth medical analysis portfolio and Kyowa Hakko’s stringent manufacturing requirements. Not like generic citicoline, Cognizin® is produced by a fermentation course of that ensures optimum purity and bioavailability. We’ve coated the a number of patents for Cognizin’s cognitive enhancement,^[14-17] which has clearly been validated by the quite a few human medical trials cited above.

Need to be taught extra concerning the detailed mechanisms and advantages of Cognizin® citicoline? Try our complete deep-dive in Cognizin® Citicoline: The Mind Choline.

The Neutonic Product Line

Let’s break down every of the three Neutonic merchandise, beginning with the vitality drink:

• Neutonic Productiveness Drink

  The Neutonic Productiveness Drink is extra than simply one other vitality drink – it’s a nootropic-enhanced, zero-sugar beverage designed to assist cognitive perform and psychological readability. At its core is a medical 500mg dose of Cognizin® citicoline, the brain-boosting compound we coated intimately above.

  

  Components Evaluation

  Every 12 fl oz can incorporates:

  • 500mg Cognizin® Citicoline
  • 400mg Rhodiola rosea Root Extract
  • 400mg L-Theanine
  • 200mg Panax Ginseng
  • 120mg Pure Caffeine
  • 100% Every day Worth of Eight B-Nutritional vitamins

  What units Neutonic other than normal vitality drinks is its emphasis on cognitive enhancement over pure stimulation. The modest 120mg caffeine dose is strategically paired with 400mg L-theanine – a 3.33:1 ratio that’s considerably larger than most rivals. This mix promotes centered vitality with out the jitters typically related to higher-caffeine alternate options (we focus on these added substances in higher element on the backside of the article).

  Distinctive Options & Advantages

  Past its nootropic core, Neutonic makes a number of formulation selections that exhibit their dedication to long-term cognitive assist:

  

  • Zero Sugar: Not like many vitality drinks that depend on sugar for his or her results, Neutonic makes use of a mix of sucralose and acesulfame potassium to keep up its nice style with out glucose spikes
  • Full B-Vitamin Complicated: Contains 100% Every day Worth of eight important B nutritional vitamins that assist vitality metabolism and cognitive perform
  • Adaptogens: Options each Rhodiola rosea and Panax ginseng at significant doses to assist fight psychological fatigue
  • Pure Caffeine: Gives clear, sustained vitality with out artificial caffeine sources

  The drink has simply 10 energy per can and is calmly carbonated, making it a refreshing different to conventional, synthetic-caffeine-heavy vitality drinks. We’ll dive deeper into the precise advantages of Rhodiola rosea, L-theanine, Panax ginseng, and the B-vitamin advanced later on this article.

  Finally, we love seeing 500mg of Cognizin® in a can, and the adaptogenic doses are clinically-supported too!

  Neutonic Productiveness Drink – Offers and Value Drop Alerts

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  Posts are sponsored partly by the retailers and/or manufacturers listed on this web page.

• Neutonic Focus Mix

  

  For these looking for the cognitive advantages of Cognizin with out caffeine, Neutonic Focus Mix gives the identical medical 500mg dose of Cognizin® citicoline in a handy powder stick pack format. Every peach mango-flavored packet incorporates:

  • 500mg Cognizin® Citicoline
  • 400mg Rhodiola Rosea Extract
  • 200mg Panax Ginseng
  • 100% Every day Worth of Eight Important B-Nutritional vitamins

  The formulation is just like the Productiveness Drink however strategically removes caffeine whereas sustaining the identical research-backed doses of adaptogens and nootropics. This makes it good for afternoon or night use when further caffeine may disrupt sleep patterns.

  Key Options

  • Zero Sugar & Zero Caffeine: Makes use of a mix of sucralose and acesulfame potassium for style with out the energy or stimulants

  

  • Medical Cognizin Dose: Options the total 500mg research-validated dose proven to assist psychological vitality and reminiscence perform
  • Full B-Complicated: Gives 100% Every day Worth of eight B-vitamins that contribute to regular psychological perform and psychological efficiency
  • Transportable Format: Simple-to-mix powder packets that may be added to water each time cognitive assist is required

  The Focus Mix is helpful for:

  • Afternoon productiveness classes while you need to keep away from late-day caffeine
  • College students or professionals preferring stimulant-free cognitive enhancement
  • Stack along with your morning espresso or pre-workout for enhanced focus
  • Journey-friendly cognitive assist that may slot in any bag or pocket

  At simply 7 energy per serving with 16 servings per field, Neutonic Focus Mix gives a handy technique to assist cognitive perform all through the day with out counting on stimulants. The zero-sugar formulation aligns with Neutonic’s dedication to wash, science-based supplementation centered on long-term mind well being quite than fast vitality hits.

  Neutonic Focus Mix – Offers and Value Drop Alerts

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  Disclosure: PricePlow depends on pricing from shops with which we now have a enterprise relationship. We work onerous to maintain pricing present, however chances are you’ll discover a higher provide.

  Posts are sponsored partly by the retailers and/or manufacturers listed on this web page.

• Neutonic Mind Capsules

  

  The Neutonic Mind Capsules characterize the model’s most complete nootropic components, offering a full day by day complement method to cognitive enhancement. Whereas sustaining the inspiration of 500mg Cognizin® citicoline discovered throughout the product line, these capsules embody further research-backed substances not discovered within the different Neutonic formulations — in addition they embody ginkgo biloba and Bacopa monnieri.

  Every 3-capsule serving incorporates:

  • 500mg Cognizin® Citicoline
  • 400mg Rhodiola Rosea Root Extract
  • 300mg Bacopa Monnieri Entire Plant Extract
  • 200mg Panax Ginseng Root Extract
  • 120mg Ginkgo Biloba Leaf Extract

  Be aware that this components does not have L-theanine inside.

  

  The components is rounded out with the entire B-vitamin advanced of weight nutritional vitamins offering 100% Every day Worth.

  Not like the drink and powder codecs, these capsules present a whole day by day nootropic stack that may be taken constantly for long-term cognitive assist. The caffeine-free components may be taken any time of day and stacked with both the Productiveness Drink or Focus Mix for enhanced results in periods of intense psychological demand.

  One bottle gives a 30-day provide at 3 capsules per day, making it a superb basis for day by day cognitive enhancement. The vegetarian-friendly capsules are made with clear inactive substances together with rice hull focus.

  Neutonic Mind Capsules – Offers and Value Drop Alerts

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  No spam, no scams.

  Disclosure: PricePlow depends on pricing from shops with which we now have a enterprise relationship. We work onerous to maintain pricing present, however chances are you’ll discover a higher provide.

  Posts are sponsored partly by the retailers and/or manufacturers listed on this web page.

The Different Key Energetic Elements within the Neutonic Platform

As promised, right here’s a breakdown on the substances that assist Cognizin:

• Rhodiola Rosea – 400mg

  Every Neutonic components incorporates a research-backed 400mg dose of Rhodiola rosea root extract, an adaptogenic herb that’s been used for hundreds of years in conventional medication to fight stress and fatigue. Fashionable analysis reveals this wasn’t simply folklore – Rhodiola has constantly demonstrated highly effective results on each psychological and bodily efficiency.

  

  The most recent research carried out on Cognizin® Citicoline was revealed in 2021, displaying improved reminiscence in wholesome older adults.^[18]

  Medical research present that Rhodiola may help scale back psychological fatigue and enhance efficiency throughout anxious conditions. In a single key research, physicians working night time shifts who supplemented with Rhodiola confirmed important enhancements in psychological efficiency and decreased fatigue in comparison with placebo.^[19]

  The adaptogenic results of Rhodiola work by serving to the physique resist non-specific stressors by a number of pathways. It helps normalize the physique’s stress response by modulating cortisol ranges and supporting wholesome neurotransmitter perform.^[20]

  When mixed with caffeine and Cognizin within the Productiveness Drink, or used by itself within the Focus Mix and Mind Capsules, Rhodiola helps present sustained psychological vitality with out the crash typically related to stimulants. The 400mg dose utilized in Neutonic’s formulation aligns with profitable medical trials displaying enhancements in psychological efficiency, focus, and stress resilience.^[21]

• Panax Ginseng – 200mg

  Panax ginseng, typically known as Asian ginseng, is likely one of the most well-researched adaptogenic herbs out there. At 200mg per serving throughout all three Neutonic formulation, this conventional herb helps assist each cognitive perform and stress response.

  Analysis reveals that Panax ginseng may help scale back psychological fatigue and enhance cognitive efficiency.^[22] The herb incorporates lively compounds known as ginsenosides that may assist defend mind cells and assist wholesome mind perform.^[23]

  

  Evaluation of the research outcomes revealed that older adults taking Cognizin confirmed statistically important enhancements in visuospatial working reminiscence (spatial span), episodic reminiscence (paired affiliate check), and general reminiscence efficiency (composite reminiscence).^[18]

  In medical research, ginseng has demonstrated the flexibility to enhance working reminiscence and scale back psychological fatigue, particularly when mixed with different nootropic compounds.^[24] The adaptogenic properties of ginseng assist the physique keep stability in periods of stress, making it a superb complement to Neutonic’s cognitive-enhancement components.

  Research counsel that ginseng’s results grow to be extra pronounced with constant day by day use, which aligns nicely with Neutonic’s varied supply codecs for various utilization events. When mixed with Cognizin citicoline, ginseng could assist present each acute cognitive advantages and long-term mind well being assist.

• L-Theanine (Productiveness Drink Solely – 400mg)

  The Neutonic Productiveness Drink has a considerable 400mg dose of L-theanine alongside its 120mg of caffeine, creating a powerful 3.33:1 theanine-to-caffeine ratio that’s considerably larger than most different dietary supplements available on the market. This particular ratio wasn’t chosen by chance – it’s designed to advertise a state of calm focus whereas lowering the potential unfavourable results of caffeine.

  L-theanine is an amino acid naturally present in tea leaves that may cross the blood-brain barrier, the place it influences a number of neurotransmitter programs.^[25] When mixed with caffeine, L-theanine helps promote a state of “alert rest” – sustaining caffeine’s cognitive advantages whereas lowering jitters and nervousness that may include stimulants.^[26]

  Analysis has proven that L-theanine works by a number of mechanisms, together with:

  • Supporting GABA manufacturing, selling rest with out sedation^[27]
  • Modulating alpha mind wave exercise, which is related to a state of “wakeful rest”^[28]
  • Serving to to scale back stress-induced will increase in blood strain and coronary heart price^[29]

  

  At 400mg, the dose in Neutonic’s Productiveness Drink is on the upper finish of studied quantities, which usually vary from 100-400mg per serving. This beneficiant dosing, particularly contemplating the reasonable 120mg of caffeine, helps create a easy, centered vitality state with out the crash or jitters typically related to conventional vitality drinks.

  Be aware that L-theanine is just included within the Productiveness Drink, not within the Focus Mix or Mind Capsules formulations — it appears to be like like Neutonic is just pairing it with their caffeinated possibility.

• Bacopa Monnieri (Capsules Solely – 300mg)

  Neutonic features a strong 300mg dose of Bacopa monnieri complete plant extract solely of their Mind Capsules components, offering added cognitive assist alongside Cognizin. This conventional herb has been used for hundreds of years in Ayurvedic medication to reinforce reminiscence and cognition.^[30]

  Analysis reveals that Bacopa monnieri operates by a number of mechanisms to assist mind well being. The herb’s lively compounds (generally known as bacosides) may help restore broken neurons, improve kinase exercise, and restore synaptic perform.^[31]

  Medical research utilizing related doses have demonstrated a number of cognitive advantages:^[32]

  

  See PricePlow’s ISSN 2024 Convention Recap, Powered by Cognizin® Citicoline

  • Improved reminiscence retention and acquisition
  • Enhanced velocity of consideration
  • Assist for processing accuracy
  • Higher working reminiscence perform

  When mixed with Cognizin citicoline, Bacopa creates a synergistic method to cognitive enhancement. Whereas Cognizin helps mind vitality and neurotransmitter manufacturing, Bacopa helps optimize the mind’s info processing and reminiscence programs.^[30]

  The 300mg dose aligns nicely with profitable medical analysis, making it a invaluable addition to Neutonic’s complete nootropic components.

• Ginkgo Biloba (Capsules Solely – 120mg)

  Lastly, the inclusion of 120mg Ginkgo biloba leaf extract in Neutonic’s Mind Capsules represents a well-dosed addition to their complete nootropic components. This standardized extract has been extensively studied for its cognitive-enhancing properties.^[33]

  At 120mg per day, Ginkgo biloba has proven spectacular leads to supporting varied elements of cognitive perform. A number of systematic critiques have demonstrated that Ginkgo may help enhance, stabilize, or gradual the development of cognitive decline.^[34]

  

  Photographs courtesy Kyowa Hakko, the sponsor of this text

  The extract incorporates a number of bioactive compounds together with flavonoid glycosides and terpene lactones, which work by a number of complementary pathways to assist mind well being. Analysis reveals these compounds can improve cerebral blood movement and supply antioxidant results, each of which can contribute to its cognitive-supporting properties.^[35]

  When mixed with Cognizin citicoline, Bacopa monnieri, and the opposite cognitive enhancers in Neutonic’s components, Ginkgo biloba helps create a well-rounded nootropic complement. This multi-ingredient method targets a number of pathways of cognitive enhancement, with Ginkgo particularly supporting reminiscence and psychological readability.

  For these looking for day by day cognitive assist, the 120mg dose of Ginkgo biloba in Neutonic Mind Capsules gives a research-backed serving that aligns with profitable medical trials, making it a strong addition to this complete nootropic components.

Type Issue Comparability: Timing Methods

With three distinct supply codecs, Neutonic’s product line provides versatile choices that can be utilized individually or strategically stacked. Right here’s how one can optimize every:

At Kyowa Hakko’s 2024 SSW Sales space, PricePlow held a panel on beverage innovation with Lou Ferrer of MacroCap Labs and Darin Decker of Utilized Diet USA.

The Productiveness Drink works finest as a morning or early afternoon complement, changing your common vitality drink or espresso. Its caffeine + L-theanine mixture makes it good for high-focus work classes or busy days.

The caffeine-free Focus Mix serves as a great afternoon possibility while you want cognitive assist with out disrupting sleep. The stick pack format permits for straightforward transport and mixing each time psychological readability is required. It may also be stacked along with your morning espresso or pre-workout for enhanced focus.

The Mind Capsules present a basis for day by day cognitive assist with their complete components together with further nootropics like Bacopa and Ginkgo. These may be taken day by day and infrequently stacked with both the drink or powder format for elevated results throughout demanding intervals.

Conclusion: A Full-Scale Cognizin®-Primarily based Product Line

In a complement trade the place influencer-backed merchandise typically fall brief on high quality and dosing, Neutonic stands out as a shining instance of doing issues proper. By partnering with Kyowa Hakko and constructing their whole product line round a medical 500mg dose of Cognizin citicoline, James Smith and Chris Williamson have confirmed their dedication to respectable cognitive enhancement over pure revenue.

Danielle Citrolo of Kyowa Hakko USA joins PricePlow Podcast Episode #153 and discusses groundbreaking new gene analysis on Cognizin Citicoline and its potential for supporting mind well being and cognitive perform.

The trio of supply codecs – from ready-to-drink cans to caffeine-free stick packs to complete day by day capsules – gives choices for any way of life or want. Every product maintains the core basis of Cognizin whereas thoughtfully incorporating complementary substances like L-theanine, Rhodiola rosea, and Panax ginseng in research-supported doses.

By providing each caffeinated and stimulant-free choices, Neutonic ensures that customers can assist their cognitive perform all through the day with out disrupting sleep cycles or constructing caffeine tolerance. The zero-sugar formulations and clear ingredient profiles additional exhibit the model’s concentrate on long-term mind well being quite than short-term vitality hits.

Whereas many movie star and influencer complement traces depend on advertising hype, Neutonic has clearly prioritized science, partnering with one of many trade’s most revered ingredient producers in Kyowa Hakko. The result’s a complete nootropic product line that we’re joyful to advocate to our readers looking for respectable cognitive assist.

You will discover all of Neutonic’s merchandise on PricePlow utilizing our value comparability instruments under. Don’t neglect to enroll in our Neutonic information alerts to remain up to date on new releases, flavors, and offers: